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关于课程
这是为期两个学期介绍性课程的第一学期课程，重点是关于有机化学结构和机制现有理论、其历史发展,基础实验观察。 该课程开放的对象是那些在化学和物理方面有充分准备分新生，它的目的是发展对原始科学的欣赏力和创新性研究所需的技能知识。
About the Course
This is the first semester in a two-semester introductory course focused on current theories of structure and mechanism in organic chemistry, their historical development, and their basis in experimental observation. The course is open to freshmen with excellent preparation in chemistry and physics, and it aims to develop both taste for original science and intellectual skills necessary for creative research.
关于J. 迈克尔麦克布莱德教授
J. Michael McBride是耶鲁大学的化学学院Richard M. Colgate教授。 在伍斯特学院和哈佛大学完成研究生工作之后教授 McBride 获得了哈佛大学物理有机化学博士学位。 他于1966年加入耶鲁大学化学学院，研究晶体生长和有机固体中的反应。 他的奖项包括 Prelog 奖章、 毕业院校诺贝尔奖得主签名奖和本科教育化学制造商协会组织的催化剂大奖。
About Professor J. Michael McBride
J. Michael McBride is the Richard M. Colgate Professor of Chemistry at Yale University. After undergraduate work at the College of Wooster and Harvard College Professor McBride earned a Ph.D. in physical organic chemistry at Harvard University. He joined the Yale Chemistry faculty in 1966, where he studies crystal growth and reactions in organic solids. His awards include the Prelog Medal, the Nobel Laureate Signature Award in Graduate Education, and the Catalyst Award of the Chemical Manufacturers Association for undergraduate education.
课程安排
1.你如何知道的？
2.力学定律，路易斯结构与共振
3.双极小值、 Earnshaw定理和Plum-Puddings
4.扫描探针显微镜
5.x 射线衍射
6.由电子密度差理解键
7.量子力学动能
8.一维波函数
9.克尼拉图形和单电子原子
10.现实与轨道近似
11.轨道矫正与汤姆生原子模型
12.重迭和原子对键
13.重迭和能量匹配
14.用XH3检查杂化理论
15.化学反应活性：单占分子轨道，最高占有分子轨道和最低未占分子轨道
16.识别官能团
17.反应监测和羰基反应性
18.氨基化合物，羧酸和烷基锂
19.氧气与化学革命（从开始到1789）
20.原子理论的兴起 (1790-1805)
21.从伯齐利厄斯到李比希和维勒（1805-1832）
22.自由基型理论 (1832年-1850)
23. 化学价理论与组成结构（1858）
24.通过同分异构体的数量确定化学结构 (1869)
25.三维空间中的模型（1869-1877）：光学异构体
26.范霍夫的碳四面体及手性
27.分子结构的书面表达
28.立体化学命名 ；消旋和分解
29.制备单一对映体和旋光的机理
30.药物测试与用途：以艾美拉唑为例
31.单一对映异构体的制备与构象能
32.Stereotopicity 与拜尔应变理论
33.构象能与分子力学
34.sharpless 氧化催化剂和环烷烃的构象
35.通过标准键了解分子结构与能量
36.键能，玻尔兹曼系数与熵
37.势能面，过渡态理论与反应机理
Class Sessions
1. How Do You Know?
2. Force Laws, Lewis Structures and Resonance
3. Double Minima, Earnshaw's Theorem, and Plum-Puddings
4. Coping with Smallness and Scanning Probe Microscopy
5. X-Ray Diffraction
6. Seeing Bonds by Electron Difference Density
7. Quantum Mechanical Kinetic Energy
8. One-Dimensional Wave Functions
9. Chladni Figures and One-Electron Atoms
10. Reality and the Orbital Approximation
11. Orbital Correction and Plum-Pudding Molecules
12. Overlap and Atom-Pair Bonds
13. Overlap and Energy-Match
14. Checking Hybridization Theory with XH3
15. Chemical Reactivity: SOMO, HOMO, and LUMO
16. Recognizing Functional Groups
17. Reaction Analogies and Carbonyl Reactivity
18. Amide, Carboxylic Acid and Alkyl Lithium
19. Oxygen and the Chemical Revolution (Beginning to 1789)
20. Rise of the Atomic Theory (1790-1805)
21. Berzelius to Liebig and Wöhler (1805-1832)
22. Radical and Type Theories (1832-1850)
23. Valence Theory and Constitutional Structure (1858)
24. Determining Chemical Structure by Isomer Counting (1869)
25. Models in 3D Space (1869-1877); Optical Isomers
26. Van't Hoff's Tetrahedral Carbon and Chirality
27. Communicating Molecular Structure in Diagrams and Words
28. Stereochemical Nomenclature; Racemization and Resolution
29. Preparing Single Enantiomers and the Mechanism of Optical Rotation
30. Esomeprazole as an Example of Drug Testing and Usage
31. Preparing Single Enantiomers and Conformational Energy
32. Stereotopicity and Baeyer Strain Theory
33. Conformational Energy and Molecular Mechanics
34. Sharpless Oxidation Catalysts and the Conformation of Cycloalkanes
35. Understanding Molecular Structure and Energy through Standard Bonds
36. Bond Energies, the Boltzmann Factor and Entropy
37. Potential Energy Surfaces, Transition State Theory and Reaction Mechanism
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