《癌症手册》(The Cancer Handbook)[PDF]

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癌症手册（The Cancer Handbook）提供关于癌症生物学和医学所有主要领域的科学和临床信息的综合概述，它与现有肿瘤学教程和参考资料的不同在于，癌症手册弥补了癌症分子生物学与临床诊断与治疗之间的差距。
涉及广泛的学科-从基本细胞生物学到所有主要器官和组织的系统肿瘤学-癌症手册的内容组织成六个主要部分：
• 细胞和组织的分子基础
• 癌症的原因和预防
• 诊断显象和影像-引导的乾涉
• 系统肿瘤学
• 人类癌症的预诊断模式
• 人类癌症的治疗


对于医学和生命科学学生以及所有在癌症领域和相关生物医学领域工作的科学工作者、临床医师和研究工作者来说，这本书是不可缺少的资源。


The Cancer Handbook

Section A - The Molecular Basis of Cell and Tissue Organization

1. Cell and Tissue Organisation
2. Regulation of the Cell Cycle
3. Overview of Oncogenesis
4. Inherited Predispositions to Cancer
5. DNA Viruses
6. RNA Viruses
7. Genetic Instability and DNA repair
8. Telomerase
9. Apoptosis
10. Signalling by steroid receptors
11. Signalling by cytokines
12. Signalling by tyrosine kinases
13. Signalling by TGF beta
14. Wnt Signal Transduction
15. Extracellular Matrix: the networking solution
16. Invasion and Metastasis
17. Angiogenesis
18. Cell Proliferation in Carcinogenesis

Section B - The Causation and Prevention of Cancer

1. Identifying Cancer Causes through Epidemiology
2. Mechanisms of Chemical Carcinogenesis
3. The Formation of DNA Adducts
4. Physical Causes of Cancer
5. Non-Genotoxic Causes of Cancer
6. Infectious Agents and Cancer
7. Short-term Testing for Genotoxicity
8. Cancer Bioassays for Pharmaceuticals a Regulatory Perspective
9. Molecular Epidemiology of Cancer
10. Dietary Genotoxins and Cancer
11. Tobacco Use and Cancer
12. Occupational Causes of Cancer
13. Anti-Genotoxins and Cancer
14. Intervention and Chemoprevention

Section C - Diagnostic Imaging and Image-Guided Intervention

Part I- Imaging Modalities in Diagnosis and Monitoring
1. Plain Film Radiography
2. Computed Tomography
3. Ultrasound
4. Magnetic Resonance Imaging
5. Nuclear Medicine Studies
6. Mammography
Part II - Diagnostic and Therapeutic Interventional Procedures
1. Percutaneous Biopsy
2. Transcatheter Therapy
3. Direct Percutaneous Tumour Therapy

Section D - Systemic Oncology

1. Introduction to the Diagnosis of Cancer
2. Skin
3. Oral cavity & major and minor salivary glands
4. Respiratory tract
5. Upper Gastrointestinal tract
6. Lower gastrointestinal tract
7. Liver, gall bladder and extrahepatic bile ducts.
8. Pancreas
9. Endocrine organs
10. Breast
11. Female reproductive system
12. Urinary tract
13. Male reproductive system
14. Lymph nodes, spleen and bone marrow.
15. Bones and joints.
16. Soft Tissues
17. Pleura and peritoneum
18. Heart
19. Neuromuscular System
20. Eye and ocular adnexa
21. Ear
Appendum. Myeloid Leukemias and related Neoplasms

Section E - Pre-clinical Models of Human Cancer

1. Advantages and limitations of models for human cancer
2. Basic Tissue Culture
3. Transgenic technology in the study of oncogenes and Tumor Suppressor Genes
4. Gene knockouts
5. Human tumours in animal hosts
6. Mammary tumour induction in animals as a model for human breast cancer
7. Mathematical models in cancer research
8. Models for tumour growth and differentiation
9. Angiogenesis models
10. Models for tumour cell adhesion and invasion
11. Tumour metastasis models
12. Models for tumour cell-endothelial cell interactions
13. Modelling Tumor Tissue Interactives
14. Models for drug development and drug resistance
15. Models for immunotherapy and cancer vaccines
16. Gene therapy models
17. Models for epithelial carcinomas
18. Models for haematological malignancies
19. Models for melanomas and sarcomas
20. Models for CNS malignancies
21. Models for endocrine cancer

Section F - The Treatment of Human Cancer

1. Mechanisms of action of cancer chemotherapeutic agents
2. Drug Resistance & Reversal
3. Molecular mechanisms of radiotherapy
4. Antibodies and recombinant cytokines
5. Genetic and Cellular Vaccines
6. Differentiation Therapy
7. Chemoprevention
8. Antisense & ribozyme therapy
9. Hormonal Therapy
10. Antiangiogenic Therapy
11. Targeting the Extracellular Matrix
12. Growth Factor Receptor Blockade
13. Signal